The Red Devils had to come from behind last week to secure a 3-2 victory in Cyprus as substitutes Marcus Rashford (2) and Anthony Martial grabbed the goals.
United sit second in Group E on six points, three behind leaders Real Sociedad, and another win at Old Trafford would edge them closer to the knockout stages.
MORE: Follow ALL the action from Old Trafford: Live - Man Utd vs Omonia
What time is Manchester United vs. Omonia?
United play host to Omonia at Old Trafford in Manchester, England. It kicks off at 8 p.m. BST on Thursday, October 13.
How to watch Manchester United vs. Omonia
UK: The match will be carried across BT Sport streaming and TV platforms.
USA: The game will be broadcast on Unimas and TUDN for Spanish listeners, which are streamed on fuboTV. Paramount+ (English) and VIX+ (Spanish) will also stream for subscribers.
Canada: Europa League matches are streamed in Canada via DAZN.
Australia: Europa League matches are streamed in Australia via Stan Sport.
Manchester United vs. Omonia lineups
Ten Hag has opted for a similar team to the one which beat Omonia in the first leg as he continues to rotate his squad.
Tyrell Malacia had a game to forget in Cyprus and has been given a chance to make amends.
Marcus Rashford starts, following his heroics in Cyprus, but French star Antony Martial is ruled out due to a back injury.
Manchester United lineup (4-2-3-1): De Gea (GK) — Dalot, Lindelof, Martinez, Malacia — Casemiro, Fred — Antony, Fernandes, Rashford — Ronaldo
Injuries have forced Lennon into a string of changes in this clash with absence of Fabiano a crucial loss for the visitors.
Omonia lineup (5-3-2): Uzoho (GK) — Matthews, Miletic, Yuste, Lang, Kitsos — Panayiotou, Charalambous, Cassama — Felipe, Kakoullis
MORE: Everton vs. Manchester United result, highlights and analysis as Cristiano Ronaldo seals victory with 700th club goal
